Medicine

Progressing ASO therapies coming from progression to implementation

.Completing rate of interests.R.S., M.S., H.G. and A.A.R. are actually coordinators of the 1M1M campaign. H.G. as well as A.A.R. are actually board of supervisors members and also R.S., M.S. and A.A.R. are actually participants of the clinical consultatory committee of N1C. A.A.R. reveals work through LUMC, which has licenses on exon-skipping technology, a few of which has actually been licensed to BioMarin and also ultimately sublicensed to Sarepta. As co-inventor of a number of these licenses, A.A.R. was allowed to a portion of nobilities. A.A.R. additionally discloses functioning as impromptu specialist for PTC Rehabs, Sarepta Therapies, Regenxbio, Dyne Rehabs, Lilly, BioMarin Pharmaceuticals Inc., Eisai, Entrada, Takeda, Splicesense, Galapagos, Sapreme, Italfarmaco and Astra Zeneca. In the past 5 years, A.A.R. also performed ad hoc consulting with for Alpha Anomeric. A.A.R. likewise states membership of the scientific advisory boards of Eisai, Hybridize Therapeutics, Silence Therapies, Sarepta Therapeutics, Sapreme and also Mitorx. Previously 5 years, A.A.R. was likewise a clinical board of advisers member for ProQR. Remuneration for A.A.R. u00e2 s consulting and recommending activities is actually paid out to LUMC. Over the last 5 years, LUMC likewise acquired speaker honoraria coming from PTC Therapies, Alnylam Netherlands, Italfarmaco and also Pfizer and also financing for deal analysis coming from Sapreme, Eisai, Galapagos, Synaffix and Alpha Anomeric. Project funding is gotten coming from Sarepta Rehabs and also Entrada via unrestricted gives. H.G. possesses nothing at all to divulge in connection with the subject matters dealt with within this document. Over the last 5 years, he has actually also received working as a consultant honoraria coming from UCB. M.S. got working as a consultant gratuity coming from Ionis, UCB, Prevail, Orphazyme, Biogen, Servier, Reata, GenOrph, AviadoBio, Biohaven, Zevra, Lilly and Solaxa previously 5 years, all unassociated to the present manuscript. R.S. possesses nothing at all to divulge in regard to the topics covered in this composition. She has obtained speaker and/or consultancy gratuity or sponsoring additions coming from Abbvie, Bial, STADA as well as Everpharma before 5 years.